期刊
EXPERT OPINION ON BIOLOGICAL THERAPY
卷 11, 期 6, 页码 775-786出版社
INFORMA HEALTHCARE
DOI: 10.1517/14712598.2011.570258
关键词
adipose-derived stem cells; cell-based therapies; HIF; hypoxia; preconditioning; tissue engineering
Areas covered: The article provides an overview of mechanisms of hypoxic responses during physiological adaptations and development. Furthermore, a synopsis of the hypoxic responses of ASCs is provided, and this information is presented in context of their utility as a major source of stem cells across the regenerative applications explored to date. Expert opinion: The reader will obtain insight into a highly specific area of stem cell research focusing on ASCs and hypoxia. In order to enhance the level of comprehension, a broader context with other stem cell and experimental systems is provided. It is emphasized that the pericellular oxygen tension is a critical regulatory factor that should be taken into account when devising novel stem cell-based therapeutic applications along with other parameters, such as biochemical soluble factors and the growth substrates.
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