期刊
EXPERT OPINION ON BIOLOGICAL THERAPY
卷 10, 期 3, 页码 421-429出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712591003586806
关键词
alemtuzumab; Campath; CD52; monoclonal antibody; MRI; multiple sclerosis
资金
- National Institute of Health
- National Multiple Sclerosis Society
- National Science Foundation
- Biogen Idec
- Teva Neuroscience
- Genzyme
- Bracco
- Questcor
- EMD Serono and Aspreva
Importance of the field. The cause and cure for multiple sclerosis (MS) remain unknown. Immunomodulatory agents are only partially effective and many patients do not tolerate the side effects or fail them. Immunosuppressive agents act non-specifically and are associated with serious complications. An emerging group of biologic agents with great potential for treatment of immune-mediated disorders such as MS are monoclonal antibodies. A review of alemtuzumab in MS is presented. Areas covered in this review. Mechanisms of action of alemtuzumab and the results of Phase II clinical trials in MS. What the reader will gain: Alemtuzumab is a humanized mAb, which targets the surface molecule CD52 on all T cell populations and other cellular components of the immune system such as thymocytes, B cells, and monocytes. Alemtuzumab, which is administered intravenously, depletes T as well as B lymphocyte populations for extended periods. Adverse effects in MS patients such as thyroid disorders and idiopathic thrombocytopenic purpura are discussed. Take home message: Alemtuzumab may hold great promise for treatment of MS patients and serve as an option for patients refractory to immunomodulatory therapies. Due to its unique mechanism of action and profound effect on MS disease activity it enhances our knowledge about pathogenic mechanisms of MS.
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