期刊
EXPERT OPINION ON BIOLOGICAL THERAPY
卷 9, 期 4, 页码 411-425出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712590902806364
关键词
adult cardiomyocyte; cardiomyocyte cell cycle; cardiomyogenesis; gene therapy; gene transfer
资金
- Argentine National Agency for the Promotion of Science and Technology (ANPCyT) [PICTO 22201, PID 268]
- Rene Favaloro University Foundation
Background: Ischemic heart disease often results in myocardial infarction, after which surviving tissue undergoes remodeling. Unfortunately, the regenerative capacity of adult cardiomyocytes is poor. Repopulating myocardium with contractile cells is an objective of regenerative medicine. The most investigated strategy is implantation of stem cells. An alternative approach is stimulating cardiomyocytes to re-enter the cell cycle and progress to mitosis and cytokinesis through gene-mediated interventions targeting cell cycle regulators, or by injecting genes coding for mitotic cytokines. Objective/methods: To summarize work done and examine postnatal growth of the heart in small rodents and large mammals to emphasize the need for caution when extrapolating results from mice and rats to humans. Results/conclusions: Today we have evidence that under certain circumstances adult cardiomyocytes re-enter the cell cycle and advances to mitosis, The problem is that our current knowledge of the triggering phenomena and the cascade of events leading to cardiomyocyte mitosis is poor.
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