期刊
EXPERT OPINION ON BIOLOGICAL THERAPY
卷 8, 期 6, 页码 769-777出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.8.6.769
关键词
allergens; allergen-specific immunotherapy; allergy; IL-10; suppression; T cell tolerance; TGF-beta; T regulatory cells
Background: Specific immune response to allergens is decisive in the development of clinically healthy or allergic states. Objective: Recent developments in the mechanisms of allergen-specific peripheral tolerance can be used for future treatment modalities. Methods: This review focuses on recent developments in allergen tolerance. Results/conclusion: The balance between allergen-specific IL-10-secreting T regulatory cells (Tr1) and T helper 2 (Th2) cells appears to be decisive in the development of allergic and healthy immune response against allergens. Induction of IL-10- and TGF-beta-producing Tr1 cells, IgG4-isotype-blocking antibodies, and suppressed mast cells, basophils and eosinophils represent major components of a relatively normalized immune response after allergen-specific immunotherapy and healthy immune response to aeroallergens in sensitized individuals.
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