期刊
EXPERT OPINION ON BIOLOGICAL THERAPY
卷 8, 期 7, 页码 923-940出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.8.7.923
关键词
antiprion drugs; prion clearance; prion diseases; prion protein; prion therapy
Background: Spongiform neurodegeneration is the pathological hallmark of individuals suffering from prion disease. These disorders, whose manifestation is sporadic, familial or acquired by infection, are caused by accumulation of the aberrantly folded isoform of the cellular prion protein (PrPc), termed PrPSc. Although usually rare, prion disorders are inevitably fatal and transferrable by infection. Objective: Pathology is restricted to the central nervous system and premortem diagnosis is usually not possible. Yet, promising approaches towards developing therapeutic regimens have been made recently. Methods: The biology of priori proteins and current models of neurotoxicity are discussed and prophylactic and therapeutic concepts are introduced. Results/condusions: Although various promising drug candidates with antiprion activity have been identified, this proof-of-concept cannot be transferred into translational medicine yet.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据