期刊
EXPERIMENTAL PHYSIOLOGY
卷 95, 期 4, 页码 561-568出版社
WILEY
DOI: 10.1113/expphysiol.2009.050815
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资金
- European Space Agency (ESA) [WISE-2005]
- National Aeronautics and Space Administration of the USA (NASA)
- Canadian Space Agency (CSA)
- French 'Centre National d'Etudes Spatiales' (CNES)
- MEDES
- Canadian Space Agency [9F007-033004/001/ST]
We compared Modelflow (MF) estimates of cardiac stroke volume (SV) from the finger pressure-pulse waveform (Finometer (R)) with pulsed Doppler ultrasound (DU) of the ascending aorta during acute changes in total peripheral resistance (TPR) in the supine and head-up-tilt (HUT) postures. Twenty-four women were tested during intravenous infusion of 0.005 or 0.01 mu g kg-1 min-1 isoprenaline, 10 or 50 ng kg-1 min-1 noradrenaline and 0.3 mg sublingual nitroglycerine. Responses to static hand-grip exercise (SHG), graded lower body negative pressure (LBNP, from -20 to -45 mmHg) and 45 deg HUT were evaluated on separate days. Bland-Altman analysis indicated that SVMF yielded lower estimates than SVDU during infusion of 0.01 mu g kg-1 min-1 isoprenaline (SVMF 92.7 +/- 15.5 versus SVDU 104.3 +/- 22.9 ml, P = 0.03) and SHG (SVMF 78.8 +/- 12.0 versus SVDU 106.1 +/- 28.5 ml, P < 0.01), while larger estimates were recorded with SVMF during -45 mmHg LBNP (SVMF 52.6 +/- 10.7 versus SVDU 46.2 +/- 14.5 ml, P = 0.04) and HUT (SVMF 59.3 +/- 13.6 versus SVDU 45.2 +/- 11.3 ml, P < 0.01). Linear regression analysis revealed a relationship (r2 = 0.41, P < 0.01) between the change in TPR from baseline and the between-methods discrepancy in SV measurements. This relationship held up under all of the experimental protocols (regression for fixed effects, P = 0.46). These results revealed a discrepancy in MF estimates of SV, in comparison with those measured by DU, during acute changes in TPR.
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