期刊
EXPERIMENTAL PARASITOLOGY
卷 132, 期 3, 页码 341-347出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2012.08.008
关键词
TcIII Armadillo (Dasypus novemcinctus novemcinctus); Venezuela; PCR-RFLP
类别
资金
- Consejo de Desarrollo Cientifico y Humanistico
- Universidad Central de Venezuela (Project CDCH) [PG 03 31 4729 06]
- Fondo Nacional de Ciencia y Tecnologia (FONACIT) [G-2005000406, G-2005000827]
- Mision Ciencia, Venezuela [2008000911-6]
Trypanosoma cruzi, etiological agent of Chagas' disease, was isolated from armadillos (Dasypus novemcinctus novemcinctus) captured in rural communities Northeastern Venezuela from Nueva Esparta State (no endemic for Chagas' disease), Monagas and Anzoategui States (endemics). The isolates, genetically typed by PCR-RFLP as belonging to the TcIII DTU, have demonstrated in murine model heterogenic parasitemia, mortality and histotropism with marked parasitism in cardiac, skeletal, and smooth myocytes that showed correlation with lymphobasophilic inflammatory infiltrates. Our finding of T. cruzi infected armadillos in Isla Margarita (Nueva Esparta State), together with reports of triatomine vectors in this region, the accentuated synanthropy of armadillos, intense economic activity, migration due to tourism and the lack of environmental education programs all of them represent risks that could cause the emergence of Chagas' disease in this area. This is the first report of the TcIII DTU in Northeastern Venezuela, thus widening the geographic distribution of this DTU. (c) 2012 Elsevier Inc. All rights reserved.
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