期刊
EXPERIMENTAL PARASITOLOGY
卷 127, 期 2, 页码 539-544出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2010.10.004
关键词
Trichinella spiralis; Allergic airway inflammation; IL-10; TGF-beta; CD4(+)CD25(+)Foxp3(+) T cell
类别
资金
- Medical Research Institute, Pusan National University Hospital
In an effort to define the mechanism underlying the host immune downregulation inherent to Trichinella spiralis infection, we compared the levels of Th1, Th2, and regulatory cytokines and CD4(+)CD25(+) forkhead box P3 (FoxP3)(+) T (T-reg) cell recruitment, as well as cellular pathology in the airway between T. spiralis infected and uninfected asthma-induced mice. After the induction of allergic airway inflammation, we noted influxes of inflammatory cells into the peribronchial tree. However, in the T. spiralis infection groups, cellular infiltration was minimal around the bronchial tree, with only a smattering of inflammatory cells. In the OVA-challenged group after T. spiralis infection, the numbers of macrophages and eosinophils in the bronchial alveolar lavage fluid were reduced by 23% and 52%, respectively, as compared to those of the OVA-challenged group. Airway hyperresponsiveness of OVA-challenged mice after T. spiralis infection was significantly suppressed as compared to the OVA-only challenged mice. The T. spiralis-infected mice exhibited a significant reduction in IL-5 concentrations relative to that noted in the OVA-challenged group (p < 0.01). Nevertheless, the regulatory cytokines IL-10 and TGF-beta levels were increased significantly as the result of T. spiralis infection, and we verified the recruitment of T-reg cells in lung draining lymph nodes via T. spiralis infection. Therefore, T-reg cells, which were recruited by T. spiralis infection, might ameliorate lung function and reduce allergic airway inflammation. (C) 2010 Elsevier Inc. All rights reserved.
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