期刊
EXPERIMENTAL PARASITOLOGY
卷 126, 期 2, 页码 254-258出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2010.05.005
关键词
Plasmodium yoelii; Plasmodium; Sporozoite; Toll-like receptor; Kupffer cell; Liver stage
类别
资金
- National Basic Research Program of China, 973 Program [2007CB513105]
- CQ CSTC [2008BA5010]
- National Natural Science Foundation of China [30771877, 30972570]
Plasmodium sporozoites suppress the respiratory burst and antigen presentation of Kupffer cells, which are regarded as the portal of invasion into hepatocytes. It is not known whether immune modulation of Kupffer cells can affect the liver stage. In the present study, we found that sporozoites inoculated into Wistar rats could be detected in the liver, spleen, and lung; however, most sporozoites were arrested in the liver. Sporozoites were captured by Kupffer cells lined with endothelial cells in the liver sinusoid before hepatocyte invasion. Pretreatment with TLR3 agonist poly(I:C) and TLR2 agonist BCG primarily activated Kupffer cells, inhibiting the sporozoite development into the exoerythrocytic form, whereas Kupffer cell antagonists dexamethasone and cyclophosphamide promoted development of the liver stage. Our data suggests that sporozoite development into its exoerythrocytic form may be associated with Kupffer cell functional status. Immune modulation of Kupffer cells could be a promising strategy to prevent malaria parasite infection. (C) 2010 Elsevier Inc. All rights reserved.
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