期刊
EXPERIMENTAL PARASITOLOGY
卷 125, 期 2, 页码 156-160出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2010.01.012
关键词
Schistosoma haematobium; Schistosoma japonicum; cAMP-dependent protein kinase
类别
资金
- National Institutes of Health/National Institute of Allergy and Infectious Diseases (USA) [N01 AI30026, R01 AI066227]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI030026, R01AI066227] Funding Source: NIH RePORTER
cAMP-dependent protein kinases (PKAs) are central mediators of cAMP signaling in eukaryotic cells. Previously we identified a cDNA which encodes for a PKA catalytic subunit (PKA-C) in Schistosoma mansoni (SmPKA-C) that is required for adult schistosome viability in vitro. As such, SmPKA-C could potentially represent a novel schistosome chemotherapeutic target. Here we sought to identify PKA-C subunit orthologues in the other medically important schistosome species, Schistosoma haematobium and Schistosoma japonicum, to determine the degree to which this potential target is conserved and could therefore be exploited for the treatment of all forms of schistosomiasis. We report the identification of PKA-C subunit orthologues in S. haematobium and S. japonicum (ShPKA-C and SjPKA-C, respectively) and show that PKA-C orthologues are highly conserved in the Schistosoma, with over 99% amino acid sequence identity shared among the three human pathogens we examined. Furthermore, we show that the recently published Schistosoma mansoni and S. japonicum genomes contain sequences encoding for several putative PKA substrates with homology to those found in Homo sapiens, Caenorhabditis elegans, and Saccharomyces cerevisiae. Published by Elsevier Inc.
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