期刊
EXPERIMENTAL NEUROLOGY
卷 261, 期 -, 页码 258-266出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2014.05.023
关键词
Stroke; Interhemispheric inhibition; Motor cortex; Rehabilitation; Electrical stimulation; Theta burst stimulation
资金
- Marsden Fund of the Royal Society of New Zealand [UOO0410]
- Rutherford Discovery Fellowship from the Royal Society of New Zealand
- Neurological Foundation Miller PhD Scholarship
- Otago School of Medical Sciences
Following a cerebral cortex injury such as stroke, excessive inhibition around the core of the injury is thought to reduce the potential for new motor learning. In part, this may be caused by an imbalance of interhemispheric inhibition (IHI); therefore, treatments that relieve the inhibitory drive from the healthy hemisphere to the peri-lesional area may enhance motor recovery. Theta burst stimulation delivered by transcranial magnetic stimulation has been tested as a means of normalizing IHI, but clinical results have been variable. Here we use a new rat model of synaptic IHI to demonstrate that electrical intracranial theta burst stimulation causes long-lasting changes in motor cortex excitability. Further, we show that contralateral intermittent theta burst stimulation (iTBS) blocks IHI via a mechanism involving cannabinoid receptors. Finally, we show that contralesional iTBS applied during recovery from cortical injury in rats improves the recovery of motor function. These findings suggest that theta burst stimulation delivered through implanted electrodes may be a promising avenue to explore for augmenting rehabilitation from brain injury. (C) 2014 Elsevier Inc. All rights reserved.
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