期刊
EXPERIMENTAL NEUROLOGY
卷 260, 期 -, 页码 69-73出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2012.11.014
关键词
Medulloblastoma; Cell of origin; Mouse models
资金
- National Cancer Institute [CA159859]
- California Institute for Regenerative Medicine [LA1-01747]
- National Brain Tumor Society
Cancer results from dysregulation of growth and survival pathways in normal stem cells and progenitors. Identifying the cells from which a tumor arises can facilitate the development of animal models and point to novel targets for therapy. Medulloblastoma is an aggressive tumor of the cerebellum that occurs predominantly in children. Recent genomic studies suggest that medulloblastoma consists of 4 major subgroups, each with distinct mutations and signaling pathway deregulations, and each potentially arising from distinct populations of stem cells and progenitors. Here we review the major types of progenitor cells in the cerebellum and discuss their role in the genesis of medulloblastoma. (C) 2012 Elsevier Inc. All rights reserved.
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