4.7 Article

The effects of chronic alcoholism on cell proliferation in the human brain

期刊

EXPERIMENTAL NEUROLOGY
卷 247, 期 -, 页码 9-18

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2013.03.020

关键词

Chronic alcoholism; Human brain tissue; Proliferation; Adult neurogenesis

资金

  1. University of Sydney
  2. National Health and Medical Research Council (NHMRC)
  3. Schizophrenia Research Institute
  4. National Institutes of Alcoholism and Alcohol Abuse (NIAAA)
  5. NSW Department of Health
  6. NIAAA (NIH (NIAAA)) [R24AA012725]
  7. NHMRC [401551]

向作者/读者索取更多资源

Neurogenesis continues in the human subventricular zone and to a lesser extent in the hippocampal subgranular zone throughout life. Subventricular zone-derived neuroblasts migrate to the olfactory bulb where survivors become integrated as intemeurons and are postulated to contribute to odor discrimination. Adult neurogenesis is dysregulated in many neurological, neurovascular and neurodegenerative diseases. Alcohol abuse can result in a neurodegenerative condition called alcohol-related brain damage. Alcohol-related brain damage manifests clinically as cognitive dysfunction and the loss of smell sensation (hyposmia) and pathologically as generalized white matter atrophy and focal neuronal loss. The exact mechanism linking chronic alcohol intoxication with alcohol-related brain damage remains largely unknown but rodent models suggest that decreased neurogenesis is an important component. We investigated this idea by comparing proliferative events in the subventricular zone and olfactory bulb of a well-characterized cohort of 15 chronic alcoholics and 16 age-matched controls. In contrast to the findings in animal models there was no difference in the number of proliferative cell nuclear antigen-positive cells in the subventricular zone of alcoholics (mean +/- SD = 28.7 +/- 20.0) and controls (27.6 +/- 18.9, p = 1.0). There were also no differences in either the total (p = 0.89) or proliferative cells (p = 0.98) in the granular cell layer of the olfactory bulb. Our findings show that chronic alcohol consumption does not affect cell proliferation in the human SVZ or olfactory bulb. In fact only microglial proliferation could be demonstrated in the latter. Therefore neurogenic deficits are unlikely to contribute to hyposmia in chronic alcoholics. (c) 2013 Elsevier Inc. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据