期刊
EXPERIMENTAL NEUROLOGY
卷 247, 期 -, 页码 314-327出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2013.01.029
关键词
Theta oscillations; Rhythmic bursting; Septum; Hippocampus; Epilepsy; Animal models; Seizures; GABAergic cells
资金
- Russian Foundation for Basic Research [06-04-48637-a, 09-04-00261-a, 12-04-00776-a, 12-04-01748-a, 13-04-00438-a]
- RF (Leading scientific schools) [HIII-850.2012.4]
Temporal lobe epilepsy (TLE) is one of the most common forms of epilepsy, characterized by hippocampal sclerosis and memory deficits. It is well-documented that intrinsic neuronal oscillations and provided by them communications between brain structures are of importance for cognition. Epilepsy disturbs these brain rhythms and presumably therefore affects memory. Here we review studies on cellular and systemic levels devoted to the TLE-induced disturbance of theta oscillations in the septohippocampal system. Special attention is paid to the role of damage of septal and hippocampal GABAergic cells in theta activity abnormalities. We also compare differences between native (in vivo) theta oscillations with those obtained in in vitro preparations of hippocampus and medial septum and find that in vitro they resemble epileptiform activity in some respects. (c) 2013 Elsevier Inc. All rights reserved.
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