期刊
EXPERIMENTAL NEUROLOGY
卷 223, 期 2, 页码 657-661出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2010.02.007
关键词
Substantia nigra; Striatum; Mouse; Stereology; Pesticide; Parkinson's disease; Caffeine
资金
- National Institutes of Health [ES010804]
- American Federation on Aging Research
- Department of Defense [W81XWH-04-1-0881]
Environmental exposures suspected of contributing to the pathophysiology of Parkinson's disease (PD) include potentially neurotoxic pesticides, which have been linked to an increased risk of PD. Conversely, possible protective factors such as the adenosine antagonist caffeine have been linked to a reduced risk of the disease. Here we assessed whether caffeine alters dopaminergic neuron loss induced by exposure to environmentally relevant pesticides (paraquat and maneb) over 8 weeks. The number of nigral neurons positive for tyrosine hydroxylase immunoreactivity (TH+) was assessed using stereological methods and found to be significantly reduced (to 60% of control) by combined pesticide treatment. Caffeine at 20 mg/kg significantly reduced TH+ neuron loss (to 85% of the respective control). The results demonstrate the neuroprotective potential of caffeine in a chronic pesticide exposure model of model of PD. (C) 2010 Elsevier Inc. All rights reserved.
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