期刊
EXPERIMENTAL NEUROLOGY
卷 222, 期 2, 页码 296-303出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2010.01.007
关键词
Amyotrophic lateral sclerosis; Frontotemporal lobar degeneration; Prostaglandin; TDP-43; Caspase
TDP-43 proteinopathy (amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions) is a newly categorized group of neurodegenerative disorders characterized by abnormal accumulation and mislocalization of nuclear TDP-43 protein in the neuronal cytoplasm 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is non-enzyniatically produced from PGD2 and plays roles in Inflammation and oxidative stress responses Indeed, 15d-PGJ(2) is up-regulated in the spinal Motor neurons in amyotrophic lateral sclerosis In this Study, biochemical and immunocytochemical analyses showed that 15d-PGJ(2) affects the proteolysis, solubility, and subcellular localization of TDP-43. similar to alterations found in TDP-43 proteinopathy Further studies revealed that a cyclopentenone ring containing an electrophilic carbon of 15d-PGJ(2) is likely to influence these phenomena These findings suggest that 15d-PGJ(2) is an endogenous modifier of TDP-43 protein in TDP-43 proteinopathy (C) 2010 Elsevier Inc All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据