期刊
EXPERIMENTAL NEUROLOGY
卷 223, 期 2, 页码 653-656出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2010.01.013
关键词
Human neural stem cell; Dopaminergic neuron; In vitro; Electrophysiology; Functional properties; Differentiation; Parkinson's disease
资金
- European Community [214706]
- NeuroStemcell [22943]
- Spanish Ministry of Science and Innovation [BIO2007-66807, PLE2009-0101]
- Carlos III Institute of Health [RETICS TerCel RD06/0010/0009]
- Foundation Ramon Areces
The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electrophysiological properties are immature and the cells require longer maturation time than possible under in vitro conditions. (C) 2010 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据