期刊
EXPERIMENTAL NEUROLOGY
卷 210, 期 2, 页码 331-338出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2007.11.002
关键词
chondroitinase ABC; corticospinal; spinal cord injury; regeneration; plasticity; proteoglycans; reaching task; forelimb
资金
- MRC [G120/818] Funding Source: UKRI
- Medical Research Council [G120/818] Funding Source: Medline
- Wellcome Trust [070467] Funding Source: Medline
Rats with a crush in the dorsal funiculi of the C4 segment of the spinal cord were treated with chondroitinase ABC delivered to the lateral ventricle, receiving 6 intraventricular injections on alternate days. In order to investigate the time window of efficacy of chondroitinase, treatment was begun at the time of injury or after a 2,4 or 7 days delay. Behavioural testing over 6 weeks showed that acutely treated animals showed improved skilled forelimb reaching compared to penicillinase controls. Forelimb contact placing recovered in treated animals but not controls, and gait analysis showed recovery towards normal forelimb stride length in treated animals but not controls. Chondroitinase-treated animals showed greater axon regeneration than controls. The treatment effect on contact placing, stride length and axon regeneration was not dependent on the timing of the start of treatment, but in skilled paw reaching acutely treated animals recovered better function. The area of chondroitinase ABC digestion visualized by stub antibody staining included widespread digestion around the lateral ventricles and partial digestion of cervical spinal cord white matter, but not grey matter. (c) 2007 Published by Elsevier Inc.
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