4.7 Article

A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus

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EXPERIMENTAL NEUROLOGY
卷 210, 期 2, 页码 793-796

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ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2007.12.018

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The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor. (C) 2007 Elsevier Inc. All rights reserved.

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