期刊
EXPERIMENTAL HEMATOLOGY
卷 42, 期 2, 页码 74-82出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.exphem.2013.11.004
关键词
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资金
- European Union [306240 (SyStemAge)]
- Grants-in-Aid for Scientific Research [26221309] Funding Source: KAKEN
Hematopoietic stem cells (HSCs) are a more heterogeneous population than previously thought. Extensive analysis of reconstitution kinetics after transplantation allows a new classifications of HSCs based on lineage balance. Previously unrecognized classes of HSCs, such as myeloid- and lymphoid-biased HSCs, have emerged. However, varying nomenclature has been used to describe these cells, promoting confusion in the field. To establish a common nomenclature, we propose a reclassification of short-, intermediate-, and long-term (ST, IT, and LT) HSCs defined as: ST < 6 months, IT > 6 months, and LT > 12. We observe that myeloid-biased HSCs or alpha cells overlap with LT-HSCs, whereas lymphoid-biased HSCs or gamma/delta cells overlap with ST-HSCs, suggesting that HSC lifespan is linked to cell differentiation. We also suggest that HSC heterogeneity prompts reconsideration of long-term ( > 4 months) multilineage reconstitution as the gold standard for HSC detection. In this review, we discuss relationships among ST-, IT-, and LT-HSCs relevant to stem cell heterogeneity, hierarchical organization, and differentiation pathways. (C) 2014 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc.
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