期刊
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 27, 期 3, 页码 933-941出版社
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2015010109
关键词
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资金
- Wellcome Trust
- European Community
- National Institute for Health Research (NIHR) Clinical Research Facility at Guy's & St. Thomas' NHS Foundation Trust
- NIHR Biomedical Research Centre based at Guy's and St. Thomas' NHS Foundation Trust
- King's College London
- ERC
- RedinRen [RD12/0021/0024]
- Spanish Society of Nephrology
- European Commission [305479, 278535, 305280, 324400, 315997]
- Institute Carlos III
- National Institute for Health Research [NF-SI-0514-10027] Funding Source: researchfish
Glycans constitute the most abundant and diverse form of the post-translational modifications, and animal studies have suggested the involvement of IgG glycosylation in mechanisms of renal damage. Here, we explored the associations between IgG glycans and renal function in 3274 individuals from the TwinsUK registry. We analyzed the correlation between renal function measured as eGFR and 76 N-glycan traits using linear regressions adjusted for covariates and multiple testing in the larger population. We replicated our results in 31 monozygotic twin pairs discordant for renal function. Results from both analyses were then meta-analyzed. Fourteen glycan traits were associated with renal function in the discovery sample (P<6.5 x 10(-4)) and remained significant after validation. Those glycan traits belong to three main glycosylation features: galactosylation, sialylation, and level of bisecting N-acetylglucosamine of the IgG glycans. These results show the role of IgG glycosylation in kidney function and provide novel insight into the pathophysiology of CKD and potential diagnostic and therapeutic targets.
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