期刊
EXPERIMENTAL GERONTOLOGY
卷 50, 期 -, 页码 114-121出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2013.12.001
关键词
Diagnosis; Plasma; Biomarker; Alzheimer; Mild cognitive impairment; Multiplex ELISA; NT-proBNP
资金
- Translational Project of the Austrian Science Funds [L429-B05]
Alzheimer's disease (AD) is a severe neurodegenerative disease. Cerebrovascular changes often accompany AD-related pathology. Despite a considerable progress in the diagnostic accuracy of AD, no blood biomarkers have been established so far. The aim of the present study was to search for changes in plasma levels of 27 vascular-related proteins of healthy controls, patients with mild cognitive impairment (MCI) and AD. In a sample of 80 participants we showed that out of these 27 proteins, six proteins were slightly changed (up to 1.5x) in AD (alpha2-macroglobulin, apolipoprotein-A1, plasminogen activator inhibitor, RAGE, Tissue Inhibitors of Metallo-proteinases-1 and Trombospondin-2) and one marker (serum amyloid A) was enhanced up to 6x but with a very high variance. However, N-terminal pro-brain natriuretic peptide (NT-proBNP) was significantly enhanced both in MCI and AD patients (1.9x). In a second analysis of a sample of 110 subjects including younger healthy controls, we confirmed that NT-proBNP has the potential to be a stable candidate protein for both diagnosis and AD disease progression. (C) 2013 Elsevier Inc. All rights reserved.
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