期刊
EXPERIMENTAL GERONTOLOGY
卷 51, 期 -, 页码 15-27出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2013.12.004
关键词
Gender; Telomere length; Systematic review and meta-analysis; Measurement methods; Epidemiology
资金
- National Heart, Lung, and Blood Institute [N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169]
- NCRR [UL1-RR-024156, UL1-RR-025005]
- National Heart, Lung and Blood Institute (NHLBI) [HL80698, HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, HL080295]
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institute on Aging (NIA) [AG023629]
- National R & D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea [0720550-2]
- BBSRC [BB/F019394/1] Funding Source: UKRI
- ESRC [ES/G00773X/1] Funding Source: UKRI
- MRC [G0500997, MR/K023209/1, MC_UP_A620_1015, G0700704, MC_UU_12017/5, MC_UU_12011/2, MC_UP_A540_1021, MR/K007017/1, MC_UU_12017/7] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: researchfish
- Chief Scientist Office [SPHSU2, CZB/4/505, ETM/55] Funding Source: researchfish
- Economic and Social Research Council [ES/G00773X/1] Funding Source: researchfish
- Kidney Research UK [RP34/2009] Funding Source: researchfish
- Medical Research Council [U1475000001, MC_UU_12017/5, MC_UP_A620_1015, MC_UU_12017/7, MR/K007017/1, MC_UU_12011/2, G0500997, MC_PC_13040, MC_UP_A620_1014, MR/K023209/1, MC_UP_A540_1021, MC_U147585824, MR/K026992/1, U1475000002, MC_UU_12011/1, G0700704] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10085, NF-SI-0508-10082] Funding Source: researchfish
- Korea Health Promotion Institute [0720550-1, A119998] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Background: It is widely believed that females have longer telomeres than males, although results from studies have been contradictory. Methods: We carried out a systematic review and meta-analyses to test the hypothesis that in humans, females have longer telomeres than males and that this association becomes stronger with increasing age. Searches were conducted in EMBASE and MEDLINE (by November 2009) and additional datasets were obtained from study investigators. Eligible observational studies measured telomeres for both females and males of any age, had a minimum sample size of 100 and included participants not part of a diseased group. We calculated summary estimates using random-effects meta-analyses. Heterogeneity between studies was investigated using sub-group analysis and meta-regression. Results: Meta-analyses from 36 cohorts (36,230 participants) showed that on average females had longer telomeres than males (standardised difference in telomere length between females and males 0.090, 95% CI 0.015, 0.166; age-adjusted). There was little evidence that these associations varied by age group (p = 1.00) or cell type (p = 0.29). However, the size of this difference did vary by measurement methods, with only Southern blot but neither real-time PCR nor Flow-FISH showing a significant difference. This difference was not associated with random measurement error. Conclusions: Telomere length is longer in females thanmales, although this difference was not universally found in studies that did not use Southern blot methods. Further research on explanations for the methodological differences is required. (C) 2013 Published by Elsevier Inc.
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