期刊
EXPERIMENTAL GERONTOLOGY
卷 48, 期 7, 页码 634-639出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2012.08.007
关键词
SIRT3; Mitochondria; Reactive oxygen species; Metabolism; Aging
资金
- German Academic Exchange Service
- Glenn Foundation for Medical Research
- Ellison Medical Foundation
- NIH [AG032375]
Mitochondria play a central role in the production of reactive oxygen species as byproducts of metabolism and energy production. In order to protect cellular structures from oxidative stress-induced damage, cells have evolved elegant mechanisms for mitochondrial ROS detoxification. The mitochondrial sirtuin, SIRT3, is emerging as a pivotal regulator of oxidative stress by deacetylation of substrates involved in both ROS production and detoxification. This review will summarize recent findings on the regulation of mitochondrial ROS homeostasis by SIRT3. (C) 2012 Published by Elsevier Inc.
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