期刊
EXPERIMENTAL GERONTOLOGY
卷 48, 期 10, 页码 1006-1013出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2012.12.001
关键词
Chronological lifespan; Replicative lifespan; Caloric restriction; Calorie restriction; Dietary restriction; Glucose; Mitochondria
资金
- NIH [R01AG039390, T32AG000057, T32ES007032]
- University of Washington Nathan Shock Center of Excellence in the Basic Biology of Aging (NIH) [P30AG013280]
Chronological aging of budding yeast cells results in a reduction in subsequent replicative life span through unknown mechanisms. Here we show that dietary restriction during chronological aging delays the reduction in subsequent replicative life span up to at least 23 days of chronological age. We further show that among the viable portion of the control population aged 26 days, individual cells with the lowest mitochondrial membrane potential have the longest subsequent replicative lifespan. These observations demonstrate that dietary restriction modulates a common molecular mechanism linking chronological and replicative aging in yeast and indicate a critical role for mitochondrial function in this process. (C) 2012 Elsevier Inc. All rights reserved.
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