期刊
EXPERIMENTAL GERONTOLOGY
卷 48, 期 7, 页码 612-613出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2012.06.017
关键词
Pregnancy-associated plasma protein-A; Insulin-like growth factors; Atherosclerosis; Aging; Cancer
资金
- National Institutes of Health [HL074871, AG028141]
- Ellison Medical Foundation
As suggested by its name, pregnancy-associated plasma protein-A (PAPP-A) plays an important role in pregnancy and fetal development (Brizot et al., 1996; Lin et al., 1974; Smith et al., 2002). On the opposite end of life's spectrum, recent studies using genetically-engineered mice indicate a newly recognized role for PAPP-A in aging and in the development of age-related disease. These latter studies will be reviewed in this article. (C) 2012 Elsevier Inc. All rights reserved.
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