期刊
EXPERIMENTAL GERONTOLOGY
卷 47, 期 12, 页码 940-949出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2012.08.009
关键词
Resveratrol; Aging markers; Longevity; Cognitive activity; Neuroprotection; Annual fish
资金
- Research Fund for the Doctoral Program of Higher Education of China [20113704110004]
- Scientific Research Starting Foundation for Returned Overseas Chinese Scholars, Ministry of Education, China [2010-609]
- Scientific Research Foundation of the Higher Education Institutions of Shandong Province, China [J09LC07]
- Shandong Provincial Natural Science Foundation of China [ZR2009DM048]
Aging research was hindered because of the long lifespan of available vertebrates. Annual fishes of Nothobranchius have become a new model organism for aging studies. Resveratrol, a natural plant-derived chemical, prolongs lifespan in many animals. Here we used the wild strain of N. guentheri, which has the mean lifespan of 12 months, to detect the effects of resveratrol on the longevity, cognitive ability and aging-related histological markers. Our results showed that the pharmaceutical treatment of resveratrol prolonged the lifespan of N. guentheri but did not affect their body size. Three behavioral assays for cognitive ability and locomotor activity demonstrated that the resveratrol-treated fish exhibited the higher rate of performances than the fish in the control group. Further data indicated that resveratrol not only had the property of protecting N. guentheri from neurodegeneration, but retarded the aging-related histological markers in lipofuscin formation and in the expression of senescence-associated beta-galactosidase activity. (C) 2012 Elsevier Inc. All rights reserved.
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