期刊
EXPERIMENTAL GERONTOLOGY
卷 47, 期 2, 页码 179-182出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2011.12.005
关键词
Leukocyte telomere length; Biological aging; Alzheimer's disease; Mild cognitive impairment; Cerebrospinal fluid
资金
- Swedish Research Council
- Swedish Foundation for Strategic Research
- ALF/LUA in Gothenburg
- Lundberg Foundation
- Torsten and Ragnar Soderberg's Foundation
- Lundbeck Foundation
- Sahlgrenska University Hospital
- Sahlgrenska Academy
- Stiftelsen Psykiatriska Forskningsfonden
- Stiftelsen Gamla Tjanarinnor
- Uppsala Universitets Medicinska Fakultet stiftelse for psykiatrisk och neurologisk forskning
- Alzheimer Foundation, Sweden
- Dementia Association, Sweden
- Novo Nordisk Foundation
Leukocyte telomere length (LTL) is associated with the aging process and may be related to cognitive aging. Previous studies have shown conflicting results whether LTL is affected in patients with Alzheimer's disease (AD). In this pilot study, we investigated LTL in a well-defined homogeneous mono-center population. Sixty consecutive patients admitted for cognitive impairment to a memory clinic were recruited. The participants included patients with AD or mild cognitive impairment (MCI) diagnosed with AD upon follow-up (n=32), patients with stable MCI (n=13), patients with other dementias diagnosed at primary evaluation or upon follow-up (n=15), and healthy controls (n=20). LTL was determined using a quantitative PCR assay. Patients with AD had similar LTL as healthy controls. Patients with stable MCI had reduced LTL both compared to AD patients (p=0.02) and controls (p=0.008). Subanalyses within the AD group showed that patients with MCI that later converted to AD had similar LTL as patients with clinical diagnosis of AD at primary evaluation and healthy controls whereas the LTL was longer compared to the stable MCI group (p=0.02). There were no correlations between LTL and the core AD biomarkers A beta(1-42), T-tau and P-tau. In conclusion, in this pilot study, patients with AD or MCI that later converted to AD had similar LTL as healthy controls. Patients with stable MCI that did not progress to dementia had reduced LTL compared to controls, which might suggest a more marked biological aging as a cause of the cognitive symptoms in this group. (C) 2011 Elsevier Inc. All rights reserved.
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