期刊
EXPERIMENTAL GERONTOLOGY
卷 46, 期 5, 页码 331-334出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2010.08.010
关键词
Fly; Lifespan; Longevity; Ndi1; Respiratory chain
资金
- National Institute on Aging [NIH RO1 AG037514]
- UCLA Older Americans Independence Center, NIH/NIA [P30-AG028748]
- Ellison Medical Foundation
- American Federation for Aging Research
- UCLA Center for Gene Environment in Parkinson's Disease
Understanding how alterations in mitochondrial function in different cells and tissues impacts the aging process remains one of the greatest challenges facing biogerontologists. Here, we discuss the recent upsurge in research in this area using the fruit fly Drosophila melanogaster as a model system. Topics that are discussed include age-related changes in mitochondrial function, mitochondrial oxidative stress and lifespan, life extension mediated by moderate knock-down of genes important for mitochondrial electron transport chain (ETC) function, and the relationship between dietary restriction and ETC activity. Finally, we review recent approaches to supplement the endogenous fly ETC with a single-subunit mitochondrial respiratory enzyme from yeast. (C) 2010 Elsevier Inc. All rights reserved.
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