期刊
EXPERIMENTAL GERONTOLOGY
卷 45, 期 2, 页码 97-105出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2009.10.009
关键词
Antagonistic pleiotropy; Sir2; Aging; Akt; Sexual differentiation
资金
- Department of Health and Human Services [AG011833]
- USC ADRC [1P50 AG05142).]
Sex-specific selective pressures are hypothesized to lead to sexually antagonistic gene functions that con tribute to phenotypes such as aging and cancer. However, relatively little is known about the identity of such genes and possible mechanisms. Here we report that nervous system-specific over-expression of wild-type p53 in Drosophila caused decreased life span in males and increased life span in females. In contrast, tissue-general over-expression produced the opposite pattern: increased life span in males and decreased life span in females. In a foxo null background, p53 life span effects in males were reversed, becoming similar to the effects in females. In contrast, a Sir:2 null background tended to reduce the magnitude of p53 effects. The data demonstrate that wild-type p53 over-expression can regulate life span independent of foxo, and suggest that foxo acts in males to produce sexually antagonistic life span effects of p53. (C) 2009 Elsevier Inc. All rights reserved.
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