期刊
EXPERIMENTAL GERONTOLOGY
卷 45, 期 5, 页码 323-330出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2009.10.006
关键词
HSP70; HSP27; Brain; Aging; Estrogen; Heat stress
资金
- Chinese National Basic Research Program [2007CB507400]
- National Center for Complementary and Alternative Medicine [RO1AT001928-03A1]
Heat shock proteins (HSPs) serve as molecular chaperones and endogenous cytoprotective factors Two of the well-studied HSPs. HSP70, and HSP27 can be significantly induced in many areas of brain by a variety of stressors. A decrease in expression of brain HSPs has been documented in aged brain. Estrogen is well known as a neuroprotective hormone, and It has been reported that estrogen can regulate HSP70 and HSP27 expression in neuronal cells. In this study, the relationship between estrogen and heat stress-induced brain HSPs expression in young and aged ovariectomized (OVX) mice was investigated. Our results show that heat stress-induced levels of HSP70 proteins and mRNA transcripts was significantly lower in brain of aged (12 month) OVX mice, compared with young (2 month) OVX mice group Estrogen supplementation (17 beta-estradiol 0 5 mg/kg for 7 days) restored heat stress-induced brain HSP70 expression and attenuated heat stress-induced brain DNA fragmentation, caspase 3 activation and mitochondrial leakage of cytochrome c and AlF in OVX mice. These results suggest that estrogen deficiency during aging down-regulates heat stress-induced brain HSP70 expression, which reveals a previously unknown link between estrogen deficiency and stress response elements. (C) 2009 Elsevier Inc. All rights reserved.
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