期刊
EXPERIMENTAL GERONTOLOGY
卷 44, 期 8, 页码 517-522出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2009.05.003
关键词
Co-stimulatory receptor; PD-1; T lymphocyte; Effector-memory T cell; Mouse; Aging
资金
- Japan Society for the Promotion of Science
- Mitsui Sumitomo Insurance Welfare Foundation
To explore whether any co-stimulatory receptor(s) for TCR signaling is involved in the age-associated decline in T-cell function, we analyzed changes in these receptors in freshly isolated mouse CD4(+) T cells during aging. Both the mRNA and protein expression levels of CTLA-4 and PD-1, negative co-stimulatory receptors, increase with aging. No such changes are observed for CD28, a positive regulatory receptor. PD-1 is highly expressed on the surface of old, but not young, mouse T cells, while the level of surface-expressed CTLA-4 is very low regardless of age. PD-1 is preferentially expressed on the surface of effector-memory (CD44(hi)CD62L(lo)) T cells, a subset that increases with aging. CD4(+)PD-1(+) T cells from old mice exhibit proliferative hyporesponsiveness. These results suggest that the up-regulation of surface-expressed PD-1 may cause the age-dependent functional decline in effector-memory T cells. (C) 2009 Elsevier Inc. All rights reserved.
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