期刊
EXPERIMENTAL EYE RESEARCH
卷 117, 期 -, 页码 126-137出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2013.07.015
关键词
biomarker; tear fluid; proteomics; protein profile; ocular disease; systemic disease; dry eye
The main focus in clinical proteomics is the discovery of new protein or peptide biomarkers which are correlated with a certain disease. Tear proteins have been investigated extensively in the past and distinct relations between the levels of certain tear proteins to different disorders have been demonstrated. In this review we attempt to summarize proteomic technologies for biomarker identification in tears and some disease related biomarkers in tear fluids that were discovered through different proteomic techniques in different conditions like dry eye, Sjogren's syndrome, contact lens wearers, glaucoma, diabetic retinopathy or cancer. Proteomic analysis of tear fluid has proven to be a promising to gain more information about the pathogenesis of diseases and lead to new diagnostic possibilities. Furthermore, biomarkers represent promising targets for drug development and can be used to monitor the disease state or treatment responses, and accordingly improve the standards of patient care. (C) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据