期刊
EXPERIMENTAL EYE RESEARCH
卷 90, 期 2, 页码 188-195出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2009.09.023
关键词
limbal epithelial stem cells; limbal epithelial stem cell deficiency; transplantation; ocular surface disease; limbal stem cell niche; human
资金
- Medical Research Council [G0700219] Funding Source: researchfish
- MRC [G0700219] Funding Source: UKRI
- Medical Research Council [G0700219] Funding Source: Medline
Our window to the world is provided by the cornea on the front surface of the eye. The integrity and functionality of the outermost corneal epithelium is essential for vision. A population of limbal epithelial stem cells (LESCs) are responsible for maintaining the epithelium throughout life by providing a constant supply of daughter cells that replenish those constantly lost from the ocular surface during normal wear and tear and following injury. LESC deficiency leads to corneal opacification, inflammation, vascularization and discomfort (Daniels et al., 2001, 2007). Cultured LESC delivery is one of several examples of successful adult stem cell therapy in patients. The clinical precedence for use of stem cell therapy and the accessibility of the transparent stem cell niche make the cornea a unique model for the study of adult stem cells in physiological conditions as well as in disease. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据