期刊
EXPERIMENTAL EYE RESEARCH
卷 90, 期 6, 页码 679-687出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2010.03.012
关键词
toll-like receptors; cornea; conjunctiva; inflammation; infection
资金
- NIH (UHCO CORE) [EY13175, EY07024, EY18113, EY07551]
- William C. Ezell Fellowship
The ability of the ocular surface to mount an immune response is in part attributed to a family of proteins called toll-like receptors (TLRs). The latter are evolutionary conserved receptors that recognize and respond to various microbes and endogenous ligands. In addition to their recognition function, TLR activation triggers a complex signal transduction cascade that induces the production of inflammatory cytokines and co-stimulatory molecules, thus initiating innate and adaptive immunity. Toll-like receptor expression at the ocular surface is modulated during infection (e.g. Herpes simplex, bacterial keratitis and fungal keratitis) as well as during various inflammatory conditions (allergic conjunctivitis and dry-eye syndrome). Here recent findings regarding TLR expression and their involvement in various ocular surface diseases are discussed. Published by Elsevier Ltd.
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