期刊
EXPERIMENTAL EYE RESEARCH
卷 87, 期 3, 页码 292-295出版社
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2008.06.002
关键词
retinal light damage; outer nuclear layer (ONL) thickness; retinal topography
资金
- National Eye Institute [EY04149, EY00871, EY12190]
- National Center for Research Resources [RR17703]
- Research to Prevent Blindness, Inc.
- Foundation Fighting Blindness
- Japan Society for the Promotion of Science (JSPS)
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR017703] Funding Source: NIH RePORTER
- NATIONAL EYE INSTITUTE [R01EY000871, R01EY004149, P30EY012190] Funding Source: NIH RePORTER
Previous studies have shown that retinal damage induced by damaging light exposure is more severe in superior retina than inferior retina when measured along the vertical meridian of eyes. However, the extent of retinal damage over all retinal regions is not clear. Albino rats were exposed to bright light (5000 lux for 6 h) and eyes removed 7 days later. Outer nuclear layer (ONL) thickness was measured along four different meridians; temporal-to-nasal (T-N), superior-to-inferior (S-I), superiotemporal-to-inferionasal (ST-IN), and superionasal-to-inferiotemporal (SN-IT). As reported previously, superior retina is more severely damaged than inferior retina along the S-I meridian. In addition, we found that the temporal retina is more severely damaged than nasal retina on the T-N meridian. Color-coded topographic maps clearly revealed that thinning of ONL was greatest at 1-1.5 mm superior and superiotemporal to the optic nerve head and that most damage was in the superiotemporal region of the fundus. For consistency in quantification of ONL thickness, using retinal sections cut along the S-I meridian is preferable to using those along the T-N meridian, since minor orientations to superior or inferior directions along the T-N meridian may cause greater variations in measured ONL thickness values in this experimental model. (C) 2008 Elsevier Ltd. All rights reserved.
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