期刊
EXPERIMENTAL DIABETES RESEARCH
卷 -, 期 -, 页码 -出版社
HINDAWI PUBLISHING CORPORATION
DOI: 10.1155/2012/459087
关键词
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资金
- NIH [R01HL69319]
- AHA [0735112N]
- Foundation for the Improvement of Postsecondary Education (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Programa de Doutorado com Estagio no Exterior, CAPES/PDEE) [010405-1]
- Cincinnati Mouse Metabolic Phenotyping Center [DK59630]
High-fructose diet is known to produce cardiovascular and metabolic pathologies. The objective was to determine whether the timing of high fructose (10% liquid solution) intake affect the metabolic and cardiovascular outcomes. Male C57BL mice with radiotelemetric probes were divided into four groups: (1) 24 h water (control); (2) 24 h fructose (F24); (3) 12 h fructose during the light phase (F12L); (4) 12 h fructose during the dark phase (F12D). All fructose groups had higher fluid intake. Body weight was increased in mice on restricted access with no difference in total caloric intake. Fasting glycemia was higher in groups with restricted access. F24 mice showed a fructose-induced blood pressure increase during the dark period. Blood pressure circadian rhythms were absent in F12L mice. Results suggest that the timing of fructose intake is an important variable in the etiology of cardiovascular and metabolic pathologies produced by high fructose consumption.
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