Global longitudinal two-dimensional systolic strain is associated with hemodynamic alterations in arterial hypertension

Arterial hypertension can lead to the progressive deterioration of the left ventricular (LV) performance. The aim of this study was to estimate the relation of global longitudinal systolic strain (GLSS) with central and systemic hemodynamics assessed by applanation tonometry and impedance cardiography in 125 hypertensive patients. Those with more impaired GLSS characterized with 1/worse diastolic function (mitral inflow early phase (E) to mitral septal annulus early diastolic velocity (e') ratio, 8.0 vs. 7.0, P=.014); 2/lower LV performance (cardiac index, 3.14 vs. 3.64 l/min/m(2); P=.007), and 3/higher afterload (systemic vascular resistance index, 2506 vs. 2107 dyn s m(2)/cm(5); P=.008). No relevant differences in, that is, gender, age, blood pressure, LV mass index, left chambers dimensions, and central blood pressure characteristics were identified. The results revealed that impaired GLSS is related to LV diastolic dysfunction and altered hemodynamics which may be markers of early systolic LV dysfunction related to arterial hypertension. (C) 2015 American Society of Hypertension. All rights reserved.