期刊
EXPERIMENTAL DERMATOLOGY
卷 24, 期 2, 页码 91-94出版社
WILEY-BLACKWELL
DOI: 10.1111/exd.12521
关键词
chronic leg ulcers; hair follicle; hair grafting; human skin; wound healing
类别
资金
- Spanish Ministry of Health, Social Services and Equality [EC11-378]
- Ministry of Economy and Competitiveness (Spain) [PI13/02172, IPT-2012-0745-300000]
- Instituto de Salud Carlos III (ISCIII) [CES09/015]
- Osakidetza-Basque Health Service (Spain)
Clinicians have long reported that hair-bearing areas tend to heal more rapidly than those lacking hair follicles. In the past decade, numerous scientific studies have corroborated clinical evidence, showing a direct nexus between the human hair follicle and the wound healing process. The migration of epithelial follicular stem cells to the skin surface to help in the wound re-epithelialization and the effect of the hair cycle on the wound healing rate underline the influence of the hair follicle in the healing process. In clinical practice, non-healing wounds are pathologies of high prevalence with significant associated burden costs for the healthcare system. As the population ages, the prevalence of this pathology is expected to increase in future years. The recent advances in understanding the biology of hair follicle stem cells have created the challenges of using this newly acquired knowledge in practical therapeutic applications. Chronic leg ulcers are an example of the targeted pathologies that urgently need better therapies. In this essay, our aim is to raise interest in this question, reviewing what is known in relation to the connections between hair follicles and wound healing, and elaborating on future directions that the field might take, including implications for clinical practice.
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