期刊
EXPERIMENTAL DERMATOLOGY
卷 23, 期 3, 页码 157-158出版社
WILEY
DOI: 10.1111/exd.12241
关键词
immune escape mechanism; myeloid-derived suppressor cell; tumor associated macrophage
类别
Immune escape mechanisms of cancers include some of the mechanisms normally used for immune homeostasis, particular those preventing autoimmunity; one of these is the polarisation of myeloid cells. Thereby, tumors, i.e. the cancerous and stromal cells, also condition distant sites like spleen and bone marrow via soluble factors and membrane vesicles such as exosomes in order to create a tumor-educated macroenvironment. Albeit these mechanisms are currently in the focus of (tumor-)immunologic research, the first evidence had been published almost 40 years ago. One of these early reports will be discussed here.
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