期刊
EXPERIMENTAL DERMATOLOGY
卷 22, 期 11, 页码 757-759出版社
WILEY
DOI: 10.1111/exd.12236
关键词
lecithin retinol acyltransferase; melanoma; prognostic marker; RPE65; vitamin A
类别
资金
- Hiege Foundation against Skin Cancer
- Olympia-Morata programme of the University Hospital Heidelberg
Metabolism inside cells differs between cancer and normal cells. Because disturbance of vitamin A metabolism might be important, we investigated expression of the enzymes lecithin retinol acyltransferase (LRAT) and RPE65 by immunohistochemistry in melanoma metastases and melanocytic nevi. Semiquantitative evaluation of this expression revealed downregulated expression of RPE65 in malignant melanoma compared with benign melanocytic nevi (P<0.001). In contrast, expression of LRAT was not significantly different (P=0.339). High LRAT expression in melanoma metastases was inversely correlated with patient survival; Kaplan-Meier analysis revealed earlier melanoma-related death (P=0.003). Expression of LRAT might, therefore, be a prognostic marker of the clinical course of melanoma.
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