期刊
EXPERIMENTAL DERMATOLOGY
卷 22, 期 7, 页码 447-452出版社
WILEY
DOI: 10.1111/exd.12163
关键词
differentiation; keratinocyte; proliferation; skin diseases; transient receptor potential vanilloid-3
类别
资金
- Hungarian ('Lendulet') [LP2011-003, TAMOP-4.2.2./A-11/1/KONV-2012-0025, OTKA 78398, OTKA 101761]
- EU [FP7-REGPOT-2008-1/229920]
The skin is our largest organ serving different tasks from barrier formation through somatosensing to hair development. Recently, members of the large trp (Transient Receptor Potential, TRP) gene family encoding proteins that form cation selective ion channel have been identified to play a crucial role in skin functions. Within the 28 different mammalian TRP channels, TRPV3 might be the most important member in the skin. This review gives an overview on functional properties of TRPV3 in skin physiology and in certain skin diseases.
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