期刊
EXPERIMENTAL DERMATOLOGY
卷 21, 期 4, 页码 249-253出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0625.2012.01447.x
关键词
cell fate; epidermal prolilferative unit; keratinocyte; progenitor cell - stem cell; stochastic
类别
资金
- Medical Research Council [MC_U105370181] Funding Source: Medline
- Wellcome Trust [092096] Funding Source: Medline
- MRC [MC_U105370181] Funding Source: UKRI
- Medical Research Council [MC_U105370181] Funding Source: researchfish
In the 1970s, studies of tissue architecture and cell proliferation were used to formulate a new model of epidermal homeostasis. This asserted that the tissue was maintained by long-lived, slow-cycling, self-renewing stem cells that generate a short-lived population of transit amplifying (TA) cells, which undergo terminal differentiation after a set number of cell divisions. It was further hypothesized that in the epidermis, the tissue was organized into clonal epidermal proliferative units (EPUs) comprising a central stem cell with surrounding TA cells, which maintain the overlying differentiated cell layers. The stem/TA and EPU hypotheses have been widely influential. Here, we first revaluate older literature, finding numerous studies that conflict with the EPU model. We then review recent large-scale lineage tracing studies in transgenic mice which exclude the stem/TA and EPU hypotheses, and reveal that the epidermis is maintained by a single population of functionally equivalent cycling progenitor cells. The outcome of individual progenitor cell divisions is random, but the probabilities of generating differentiated and progenitor cell daughters are equal, so that homeostasis is maintained across the progenitor population. We reconcile this model with the older literature and place the epidermis in the context of other tissues that are also maintained by continually cycling cells with stochastic fate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据