期刊
EXPERIMENTAL DERMATOLOGY
卷 20, 期 10, 页码 845-847出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1600-0625.2011.01325.x
关键词
IL-17; IL-22; lesion tissue; palmoplantar pustulosis; serum
类别
资金
- Japan Society for the Promotion of Science (JSPS) [22591235]
- Asahikawa Medical University
- Grants-in-Aid for Scientific Research [22591235] Funding Source: KAKEN
Recent findings about the pathogenesis of pustulosis palmaris et plantaris (PPP), also known as palmoplantar pustulosis, suggest that IL-17 expression in the acrosyringium as well as infiltration of IL-17 positive cells, e. g. Langerhans cells may play important roles. However, to date, it has not been established whether circulating IL-17 related cytokines are involved in PPP. We studied the circulating IL-17 related cytokines as well as the mRNA levels in lesional skin. IL-17 related cytokine mRNAs were increased in the PPP lesions compared with the control tissues (five patients vs five controls). The serum levels of TNF-alpha, IL-17, IL-22 and IFN-gamma also were significantly increased in PPP, but not IL-23 and IL-8 (48 patients vs 20 controls). Our findings document that not only the serum IL-17 but also tissue IL-17 are elevated in PPP and may be in the pathogenesis of this disorder.
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