期刊
EXPERIMENTAL DERMATOLOGY
卷 19, 期 8, 页码 E73-E79出版社
WILEY
DOI: 10.1111/j.1600-0625.2009.00994.x
关键词
honey; keratinocytes; major royal jelly protein 1; skin; wound healing
类别
资金
- New and Emerging Applications of Technology programme of the Department of Health
- Medical Research Council, UK
- MRC [G0500729] Funding Source: UKRI
- Asthma UK [06/026] Funding Source: researchfish
- Medical Research Council [G0500729] Funding Source: researchfish
Honey has been used since ancient times as a remedy in wound healing. However, even though the results from randomized clinical trials document that honey accelerates wound healing, no study dealing with its influence on human skin cells (epidermal keratinocytes and dermal fibroblast) has been performed. We demonstrate that keratinocytes, which are known to be involved in wound healing, are responsible for elevated production of mediators including cytokines (TNF-alpha, IL-1 beta and TGF-beta) and matrix metalloproteinase-9 (MMP-9) after incubation with honey. Real-time PCR was performed for the quantification of mRNA level of selected cytokines and MMP-9. Furthermore, we show that the increased level of MMP-9 in the epidermis following incubation with honey leads to degradation of type IV collagen in the basement membrane. These data indisputably demonstrate that honey activates keratinocytes and support the findings that honey may accelerate wound healing process.
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