期刊
EXPERIMENTAL CELL RESEARCH
卷 321, 期 2, 页码 209-218出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2013.12.019
关键词
CUB-domain containing protein 1; Bone morphogenetic protein 4; Transforming growth factor-beta; Epithelial-mesenchymal transition; Extracellular signal-regulated kinase
资金
- Japan Society for the Promotion of Science [23591008, 24790674, 23390194]
- Ministry of Health, Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [23591008, 23390194, 24790674] Funding Source: KAKEN
The prognosis of pancreatic cancer is dismal due to the frequent metastasis and invasion to surrounding organs. Numerous molecules are involved in the malignant behavior of pancreatic cancer cells, but the entire process remains unclear. Several reports have suggested that CUBdomain containing protein-1 (CDCP1) is highly expressed in pancreatic cancer, but its impact on the invasive growth and the upstream regulator remain elusive. To clarify the role of CDCP1 in pancreatic cancer, we here examined the effects of CDCP1 knockdown on the cell behaviors of pancreatic cancer cells. Knockdown of CDCP1 expression in Panc-1 resulted in reduced cellular migration accompanied by the increased expression of E-cadherin and decreased expression of N-cadherin. Knockdown of CDCP1 attenuated the spheroid formation and resistance against gemcitabine, which are some of the cancer stem cell-related phenotypes. Bone morphogenetic protein 4 (BMP4) was found to induce CDCP1 expression via the extracellular signal regulated kinase pathway, suggesting that CDCP1 has a substantial role in the BMP4-induced epithelialmesenchymal transition. These results indicate that CDCP1 represses the epithelial phenotype of pancreatic cancer cells. (C) 2013 Elsevier Inc. All rights reserved.
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