期刊
EXPERIMENTAL CELL RESEARCH
卷 325, 期 1, 页码 38-43出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2014.03.012
关键词
Mitochondrial disease; Treatments; Zinc-finger nucleases; TALENs
资金
- Newcastle University Centre for Brain Ageing and Vitality - Biotechnology and Biological Sciences Research Council
- Engineering and Physical Sciences Research Council
- Economic and Social Research Council
- Medical Research Council [G0700718]
- UK NIHR Biomedical Research Centre in Age and Age Related Diseases award
- MRC Centre for Neuromuscular Disease [G000608-1]
- Wellcome Trust Centre for Mitochondrial Research [096919/Z/11/Z]]
- Lily Foundation
- UK NHS Specialist Commissioners Rare Mitochondrial Disorders of Adults and Children Service
- MRC [G0700718, MR/K006312/1] Funding Source: UKRI
- Medical Research Council [MR/K006312/1, G0700718] Funding Source: researchfish
- NIHR Newcastle Biomedical Research Centre [BH111030] Funding Source: researchfish
Mitochondrial DNA diseases are common neurological conditions caused by mutations in the mitochondrial genome or nuclear genes responsible for its maintenance. Current treatments for these disorders are focussed on the management of the symptoms, rather than the correction of biochemical defects caused by the mutation. This review focuses on the molecular effects of mutations, the symptoms they cause and current work focusing on the development of targeted treatments for mitochondrial DNA disease. (C) 2014 The Authors. Published by Elsevier Inc.
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