期刊
EXPERIMENTAL CELL RESEARCH
卷 329, 期 1, 页码 148-153出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2014.07.017
关键词
DNA damage; Transcription regulation; Transcription coupled repair; Histone dynamics; Chromatin modifications; Genome integrity
资金
- European Research Council [ERC-2013-StG-336427 EpIn]
- French National Research Agency [ANR-12-JSV6-0002-01]
- Who am I? laboratory of excellence
- EDF Radiobiology program [RB 2014-01]
- Fondation ARC [SFI20121205449]
- University Pierre Marie Curie
DNA damage interferes with the progression of transcription machineries. A tight coordination of transcription with signaling and repair of DNA damage is thus critical for safeguarding genome function. This coordination involves modulations of chromatin organization. Here, we focus on the central role of chromatin dynamics, in conjunction with DNA Damage Response (DDR) factors, in controlling transcription inhibition and restart at sites of DNA damage in mammalian cells. Recent work has identified chromatin modifiers and histone chaperones as key regulators of transcriptional activity in damaged chromatin regions. Conversely, the transcriptional state of chromatin before DNA damage influences both DNA damage signaling and repair. We discuss the importance of chromatin plasticity in coordinating the interplay between the DDR and transcription, with major implications for cell fate maintenance. (C) 2014 Elsevier Inc. All rights reserved.
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