期刊
EXPERIMENTAL CELL RESEARCH
卷 323, 期 2, 页码 346-351出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2014.02.028
关键词
Porous; Surface morphology; Mechanical property; Cell-scaffold interaction; Cell compatibility
资金
- National Natural Science Foundation of China [51375292]
- National Youth Foundation of China [51105239]
The structure of a tissue engineering scaffold plays an important role in modulating tissue growth. A novel gelatin chitosan (Gel-Cs) scaffold with a unique structure produced by three-dimensional printing (3DP) technology combining with vacuum freeze-drying has been developed for tissueengineering applications. The scaffold composed of overall construction, micro-pore, surface morphology, and effective mechanical property. Such a structure meets the essential design criteria of an ideal engineered scaffold. The favorable cell matrix interaction supports the active biocompatibility of the structure. The structure is capable of supporting cell attachment and proliferation. Cells seeded into this structure tend to maintain phenotypic shape and secreted large amounts of extracellular matrix (ECM) and the cell growth decreased the mechanical properties of scaffold. This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique structure, which acts to support cell growth. (c) 2014 Elsevier Inc. All rights reserved.
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