期刊
EXPERIMENTAL CELL RESEARCH
卷 329, 期 2, 页码 248-254出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2014.08.017
关键词
Hematopoietic stem cell; Cytokine; Inflammation; Interferon; Interleukin; Myeloproliferative neoplasm
资金
- NIAID NIH HHS [T32 AI007334] Funding Source: Medline
- NIDDK NIH HHS [K01 DK098315] Funding Source: Medline
Hematopoiesis is the hierarchical process in which all lineages of blood cells are produced by self-renewing hematopoietic stem cells (HSCs) in the bone marrow (BM). While the regulatory factors that maintain proper HSC function and lineage output under normal conditions are well understood, significantly less is known about how HSC fate is regulated in response to inflammation or disease. As many blood disorders are associated with overproduction of pro-inflammatory cytokines, significant interest has emerged in understanding the impact of these factors on HSC function. In this review we highlight key advances demonstrating the impact of pro-inflammatory cytokines on the biology of HSCs and the BM niche, and address ongoing questions regarding their role in normal and pathogenic hematopoiesis. (C) 2014 Elsevier Inc. All rights reserved.
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